Kamagra Polo 100 mg is a drug used to overcome erectile dysfunction in men. The best thing about this medicine is that it is manufactured in the form of chews that permits a customer to consume it easily without using water. Moreover, these chews are present in different fruity flavor, hence, a patient does not have to experience a bad taste while chewing them. Loaded with sildenafil, Kamagra Polo 100 mg tablet is a guaranteed source to spice up the sexual life and to enjoy a maximum number of orgasms. A headache, nausea, flushing and stomach upset are some of the most common adversities associated with the use of Kamagra Polo. The drug must be stored in a cool and dry place and must not be used by women and underage boys.
Sildenafil in Clinical Research
“Sildenafil prevents indomethacin-induced gastropathy in rats: the role of leukocyte adherence and gastric blood flow” by Camila L Santos et al studied how the administration of sildenafil in rats could prevent gastropathy induced by indomethacin.
It is known that nitric oxide is of particular importance in the regulation of defense system of the mucosa of the stomach. Sildenafil, on the other hand, is an inhibitor of an enzyme phosphodiesterase type 5 which is responsible for elevating the levels of cGMP. This elevation in the levels of cyclic Guanosine Monophosphate is also involved in the mediation of different actions of nitric oxide. The basic aim of this study was to check whether the administration of sildenafil could increase the protection of the mucosal service of the stomach in the rats who were suffering from gastropathy induced by indomethacin. For this purpose, sildenafil was administered in the rats in different quantities like 1 mg, 4 mg, and 10 mg. This administration was included in the pretreatment and later, the rats were observed for gastric damage. It was seen that the administration of sildenafil reduced the extent of gastric damage in the mice and also reduced the level of myeloperoxidase which is affected by indomethacin. It was also seen that the adhesion of the leucocyte induced by indomethacin was also decreased by sildenafil. Overall results were calculated and it was observed that the administration of sildenafil citrate in rats worked through certain mechanisms dependent on nitric oxide and prevents these rats from developing gastropathy due to the use of indomethacin. This was probably due to a maintained blood flow towards the stomach and a reduced adhesion of leucocytes.
Another study named “Compliance of sildenafil treatment for erectile dysfunction and factors affecting it” by B-P Jiann et al focused on the compliance of the patients to the treatment with sildenafil citrate and the factors which affect this compliance. In order to assess the compliance of the patients towards the treatment, the factors which were affecting it and the reasons for withdrawal from the treatment, a questionnaire was prepared. This questionnaire was later mailed to 2139 different subjects who had been prescribed sildenafil citrate for the treatment of erectile dysfunction in a time period of 1999 to 2002. Out of 2139 people, 726 subjects responded to this questionnaire. The ages of these males were around 67 years. After evaluating the response from the questionnaires, it was deduced that a 67 percent of the people responded to the therapy with sildenafil. 43 percent of the people who used sildenafil also stated that they continued using it for a long period of time while 57 percent of them said that they did not use it up to 3 years of follow-up treatment. The reasons for withdrawal were also recorded and were found to be a loss of interest, the high price of sildenafil and unavailability of getting sildenafil. Those who continued taking sildenafil were found to be engaged in trying out other treatment options for ED as compared to those who discontinued it. It was concluded that the leading reason for withdrawal of sildenafil was due to its effect on the expectations.